Feifei Li , Mengwen Jia

College of Science, Hebei University of Technology, Tianjin 300401, China
*This work was supported by a grant from Graduate Creative Ability Training funded projects in Hebei Province (220056)
Author    Correspondence author
Cancer Genetics and Epigenetics, 2016, Vol. 4, No. 1   doi: 10.5376/cge.2016.04.0001
Received: 08 Aug., 2016    Accepted: 09 Sep., 2016    Published: 12 Sep., 2016

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

LI F.F. and JIA M.W., 2016, Identify the Relationship between ncRNA and Ion Channel Using Multiple-network, Cancer Genetics and Epigenetics, 4(1): 1-10 (doi: 10.5376/cge.2016.04.0001)

Non-coding RNAs and ion channels as biologically important molecules involved in many important biological processes, in particular they are involved in the development process of cancers, cardiovascular diseases and neurodegenerative diseases. Non-coding RNAs account for the majority of the human genome, and regulate the expression of a number of protein-coding genes. Study of the relationship between non-coding RNAs and ion channels will help us better understand the mechanism of diseases; however, the current research about it was not sufficient. In this paper, we obtained probes information of human protein-coding genes and ncRNAs using probe re-annotation method. A high quality Multi co-expression network was built combined with Alzheimer’s disease gene expression data sets, ion channel protein-coding genes, the gene expression correlation of each gene expression profile, and the consistency of co-expression direction in the gene expression profiles. Construction of multi co-expression network, then we analyzed the features of the network, predicted ncRNAs function, analyzed the relationship between the ncRNAs and ion channel genes and the relationship between ncRNAs and Alzheimer's disease-related genes. We found that ncRNAs and ion channels have relationships between the function and expression, VDAC2 and 5 ncRNAs may be involved in the pathogenesis of Alzheimer’s disease.

Non-coding RNA; Ion channel; Co-expression network; Alzheimer’s disease