Min  Yang¹ , Wenqian  Li¹ , Dongwei Zhang^{1, 2}

1 Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China
2 Heilongjiang Academy of Medical Sciences, Harbin, Heilongjiang, China
Author    Correspondence author
Cancer Genetics and Epigenetics, 2018, Vol. 6, No. 4   doi: 10.5376/cge.2018.06.0004
Received: 03 Sep., 2018    Accepted: 08 Oct., 2018    Published: 26 Oct., 2018

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Yang M., Li W.Q., and Zhang D.W., 2018, The progress of IGF2 in breast cancer research, Cancer Genetics and Epigenetics, 6(4): 25-32 (doi: 10.5376/cge.2018.06.0004)

Breast cancer is the first malignant tumor in Chinese women, which seriously threatens the health of the patients. The research on breast cancer-related genes and therapeutic targets has been a hot topic in the research field. Insulin-like growth factor 2 (IGF2 insulin-like growth factor 2), with the development of precision medicine, the treatment of breast cancer tends to be more and more individualized with the development of various malignant tumors, Association of IGF2 gene with invasiveness, risk if breast cancer, progression rate and prognostic therapy, the author summarized the important achievements of IGF2 gene in the study of breast cancer, including the structure and function of IGF2 gene, the cloning and expression of IGF2 gene, and the relationship between IGF2 gene and breast cancer, etc.

IGF2; Breast cancer; Gene expression; Methylation