Chenggang Mao^1* , Xiaochun Zhou^1* , Yidao Jiang¹ , Lijia Wan¹ , Zezhang Tao²

1 Department of Otolaryngology-Head and Neck Surgery, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, 434020, China
2 Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, 430060, China
*These authors contributed equally to this work
Author    Correspondence author
Cancer Genetics and Epigenetics, 2019, Vol. 7, No. 1   
Received: 24 Jan., 2019    Accepted: 13 Feb., 2019    Published: 22 Feb., 2019

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

The associations of the P53 codon 72 polymorphism and risk of nasopharyngeal carcinoma(NPC) were inconclusive in several epidemiological studies. In order to get a more consistent result in these two, we conducted these 9 articles of the meta-analysis and systemic reviews to investigate relationships. An exhaustive search was conducted by us in PubMed and Embase databases up to March 2015. Only the studies consisting of NPC patients who were diagnosed by pathological methods were considered. The 95% confidence intervals (CIs) of odds ratios (ORs) were used to assess the association and Review Manager (RevMan) 5.2 software were used to perform statistical analyses. Consequently, there were nine studies were selected, which include 1,588 cases and 1,925 controls met the included criteria. Ultimately, systematic meta-analyses were used to extract relevant data and further analyze. The conclusions indicated that the persons who carried Pro/Pro genotype have an increased susceptibility of NPC compared with the persons who carried homozygote Arg/Arg genotype and heterozygote Arg/Pro [OR 0.59, 95%CI 0.48-0.72; OR 0.66, 95% CI 0.46-0.93]. For Arg allele, the persons with homozygote Pro/Pro genotype have an obviously increased susceptibility to NPC to the persons with an integrated Arg genotype (Arg/Pro + Arg/Arg) [OR 0.62, 95%CI 0.45-0.68]. For Pro allele, the conclusions showed the persons with Arg/Arg genotype have an obviously increased risk of NPC compared with the persons with an integrated Pro genotype (Arg/Pro + Pro/Pro) [OR 0.75, 95%CI 0.64-0.87]. To sum up, the conclusions of the meta-analysis indicate that Homozygote Pro/Pro genotype obviously increased NPC risk in the P53 codon 72; and Arg allele significantly decreased the susceptibility to NPC.

TP53 codon 72; Nasopharyngeal carcinoma; Meta-analysis; Polymorphism