Jie  Wang

Zhuji People’s Hospital, Zhuji, 311800, Zhejiang, China
Author    Correspondence author
Cancer Genetics and Epigenetics, 2024, Vol. 12, No. 2   
Received: 08 Mar., 2024    Accepted: 15 Apr., 2024    Published: 27 Apr., 2024

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

The interaction mechanism between epigenetic modifications and cancer genomics is a highly anticipated topic in the current field of cancer research. With the continuous advancement of technology, researchers' in-depth understanding of these two fields provides new perspectives for revealing the occurrence and development of cancer. Epigenetic modifications and cancer genomics play a crucial regulatory role in cell fate, gene expression, and tumorigenesis. The application of high-throughput sequencing technology enables researchers to have a more comprehensive understanding of the distribution and impact of epigenetic modifications in the cancer genome. However, the current challenges faced by cancer research, such as cancer heterogeneity and treatment resistance, further indicate the urgency of in-depth research on this interaction mechanism. This review introduces the basic concepts of cancer genomics and epigenetic modifications, explores the regulatory role of epigenetic modifications in the occurrence and development of cancer, and discusses the mutual influence between epigenetic modifications and cancer genomics. The aim is to deepen the understanding of the molecular mechanisms of cancer and provide scientific basis for precision medicine and personalized treatment.

Epigenetic modifications; Cancer genomics; DNA methylation; Cancer driving genes; Individualized treatment