Wei  Zhang

Zhejiang Cancer Hospital, Hangzhou, 310022, Zhejiang, China
Author    Correspondence author
Cancer Genetics and Epigenetics, 2024, Vol. 12, No. 3   
Received: 13 Mar., 2024    Accepted: 22 Apr., 2024    Published: 05 May, 2024

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Gastric cancer a leading cause of cancer-related deaths worldwide, necessitating a comprehensive understanding of its underlying mechanisms. This study explores the genetic and epigenetic regulation in gastric cancer, highlighting the critical roles of oncogenes, tumor suppressor genes, and chromosomal aberrations. Genome-wide association studies (GWAS) are discussed for their contributions to identifying genetic predispositions. Additionally, the study delves into epigenetic mechanisms, including DNA methylation, histone modifications, and non-coding RNAs, and their impact on gene expression. The interplay between genetic and epigenetic changes is examined, emphasizing the interaction effects and the benefits of integrated genomic and epigenomic approaches. Clinical implications are addressed, focusing on diagnostic and prognostic biomarkers, therapeutic targets, and the potential for personalized medicine. The study also considers the challenges and limitations in studying gastric cancer, such as its complexity, technical constraints, and biological variability. Future directions point to the promise of emerging technologies, integrative and multi-omics approaches, and global epidemiological studies in advancing the understanding and treatment of gastric cancer. The study concludes by summarizing key findings and underscoring the importance of ongoing research in this field.

Gastric cancer; Genetic regulation; Epigenetic mechanisms; Biomarkers; Personalized medicine