Anita wang

Author    Correspondence author
Cancer Genetics and Epigenetics, 2024, Vol. 12, No.   
Received: 01 Jan., 1970    Accepted: 01 Jan., 1970    Published: 11 Oct., 2024

RNA interference (RNAi) is a natural process that induces gene silencing through small interfering RNA (siRNA) and microRNA (miRNA). In recent years, RNAi has shown great potential in cancer therapy, particularly in targeting HPV-induced cervical cancer. By silencing the oncogenes E6 and E7, RNAi can inhibit tumor growth and enhance the efficacy of chemotherapeutic drugs. This study reviews the application of RNAi in cervical cancer treatment, including its biogenesis, gene silencing mechanisms, and performance in both in vitro and in vivo studies. It also discusses the advantages and challenges of RNAi compared to traditional therapies and analyzes the synergistic effects of RNAi with chemotherapeutic drugs. The research demonstrates that RNAi exhibits significant anticancer effects in both in vitro and animal models, especially in studies targeting HPV genes. Additionally, the combination of RNAi with chemotherapeutic drugs like cisplatin significantly increases cancer cell sensitivity to treatment. By deepening the understanding of RNAi mechanisms, this study provides theoretical support for developing RNAi-based therapies for cervical cancer. RNAi not only specifically silences cancer-related genes but also reduces tumor resistance to chemotherapy, thereby improving therapeutic outcomes. While RNAi holds great promise for cervical cancer treatment, challenges such as delivery efficiency and off-target effects remain to be addressed. Future research should focus on optimizing RNAi delivery systems and identifying new targets to advance RNAi's clinical application.