Yue Gu

Author    Correspondence author
Cancer Genetics and Epigenetics, 2024, Vol. 12, No.   
Received: 01 Jan., 1970    Accepted: 01 Jan., 1970    Published: 12 Oct., 2024

The progression of colon cancer is subject to sophisticated regulation by a complex network of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs). These molecules exert a significant influence on processes such as tumorigenesis, metastasis, and the development of chemoresistance. Our research delves into the regulatory functions of lncRNAs and miRNAs in the context of colon cancer, emphasizing their interplay and underlying mechanisms.Specifically, lncRNAs, including TTN-AS1, FEZF1-AS1, and CCAT2, have been demonstrated to facilitate the progression of colorectal cancer (CRC) by acting as molecular sponges for particular miRNAs, consequently perturbing the expression of genes that regulate cellular activities such as proliferation, migration, and invasion. For example, TTN-AS1 augments the progression of CRC through its interaction with the miR-376a-3p/KLF15 axis, whereas FEZF1-AS1 exerts its regulatory effects via the miR-363-3p/PRRX1 pathway.Furthermore, lncRNAs such as PART1 and CACS15 have been implicated in conferring chemoresistance to CRC. These lncRNAs interact with miR-150-5p/miR-520h and miR-145, respectively, modulating critical signaling pathways like Wnt/β-catenin and ABCC1. The current study also contemplates the feasibility of utilizing lncRNA-miRNA interactions as emerging biomarkers and therapeutic targets for the management of CRC.The elucidation of the intricate ceRNA networks, involving both lncRNAs and miRNAs, is anticipated to unlock new avenues for innovative diagnostic and therapeutic strategies in the field of CRC research. This comprehensive understanding of the molecular crosstalk within these networks is vital for the development of targeted interventions and personalized treatment regimens.