Salil Vaniawala , Avani Kathiriya , Pankaj Gadhia

Molecular Cytogenetic Unit, S. N. Gene Laboratory and Research Centre, Surat, India
Author    Correspondence author
International Journal of Clinical Case Reports, 2015, Vol. 5, No. 4   doi: 10.5376/ijccr.2015.05.0004
Received: 25 Nov., 2014    Accepted: 17 Dec., 2014    Published: 30 Jan., 2015

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Vaniawala et al., 2015, Trisomy 6 as Sole Cytogenetic Abnormality in Acute Myeloid Leukemia “A Case Series”, International Journal of Clinical Case Reports, Vol.5, No.4 1-3 (doi:  10.5376/ijccr.2015.05.0004)

Identification of cytogenetic abnormalities plays an important role in the diagnosis and prognosis of leukemias. We report three cases of trisomy 6 as sole cytogenetic abnormality in acute myeloid leukemia (AML). Short-term unstimulated bone marrow culture showed two cases of AML-M1 and one case of AML-M2 with trisomy 6. It is known that trisomy 6 is a rare numerical abnormality and prognostic significance is not well established. More studies are required to assign the role of trisomy 6 in the development of leukemia as well as in prognosis.

Bone marrow; G-Banding; Karyotype; AML; Trisomy 6