Soumeya Nora Fedala¹ , Farida Chentli² , Djamila Meskine² , Ali El Mahdi Haddam²

1. Department of endocrinology bab el oued hospital, Algeria
2. Department of endocrinology bologhine hospital, Algeria
Author    Correspondence author
International Journal of Clinical Case Reports, 2015, Vol. 5, No. 28   doi: 10.5376/ijccr.2015.05.0028
Received: 04 Apr., 2015    Accepted: 13 Jun., 2015    Published: 03 Jul., 2015

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Soumeya Nora Fedala, Farida Chentli, Djamila Meskine and Ali El Mahdi Haddam, 2015, Interruption Syndrome Pituitary Stalk: About 8O Cases, International Journal of Clinical Case Reports, 5(28) 1-8 (doi: 10.5376/ijccr.2015.05.0028)

Summary We report the study of 80 patients (65 M, 15 F) with Interruption Syndrome Pituitary Stalk. They had consulted for delay stature n: 65 and polyuropolydipsic syndrome n: 2. The mean age at diagnosis was 7±2.8 years. Delivery dystocia was noted in 18.7%. Neonatal hypoxia has been reported in 5%. The average size of patients was -.3±DS/M (Sempe). Micropenis ± cryptorchidism was present in 50%. Pituitary hypoplasia represents 91.2% of abnormality. The post pituitary gland is ectopic in 37.5%: infundibular place (90%) Tubercinerum (10%). In 3.7%, it is not found. The number of ectopic and unseen post pituitary gland is significantly higher (p<10-6) when the stalk is discontinued (n: 28). Than when pituitary gland is normally (n=3).

The genetic study performed showed no molecular defect (PROP 1 PIT1, LHX3, LHX4, HESX1).

SITP MRI; GH deficiency; Multiple hormone deficiencies; Malformatives abnormalities; Monitoring