Phenotypic and Evolutionary Characteristics of Precocious Puberty: About 30 Cases  

Haddam  A.E.M.1 , Meskine  D.1 , Chentli  F.2 , Fedala  S.N.2
1.Department of Endocrinology, EPH Bologhine Algiers, Algeria
2.Department of Endocrinology, CHU BEO Algiers, Algeria
Author    Correspondence author
International Journal of Clinical Case Reports, 2015, Vol. 5, No. 49   doi: 10.5376/ijccr.2015.05.0049
Received: 21 Jul., 2015    Accepted: 22 Aug., 2015    Published: 10 Dec., 2015
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This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Preferred citation for this article:

Fedala S.N., Chentli F., Meskine D., Haddam A.E.M., 2015, Phenotypic and Evolutionary Characteristics of Precocious Puberty: About 30 Cases, International Journal of Clinical Case Reports, 5(49) 1-5 (doi: 10.5376/ijccr.2015.05.0049)


Thirty children with precocious puberty (PP) were followed in Endocrinology department, from 2000 to 2015. The disorder was more common in girls than in boys with a sex ratio (F/M) of 3.

The mean age at diagnosis was 4.2 ± 1.4 years (1-8.5) in girls and 5.6 ± 1.4 years (17 months - 9 years) in boys. The average delay for consultation, relative to the ascertainment of the first sign of that early puberty is 2.5 years (6 months - 6 years) in girls and 3.2 years (6 months - 4 years) in boys.

The PP was scalable for all boys and half of girls (52.5%). Pubertal precocity was of central origin (CPP) in 83% of girls and in 70% of cases it was idiopathic. In boys organic cause was noted in all of them, it was central in 28.5%. The peripheral origin noted in 72% of cases is related to a congenital adrenal hyperplasia.

Precocious puberty; Secondary sexual characteristics; Brain MRI; Congenital adrenal hyperplasia; Hypothalamic hamartoma
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