Research Article

The Impact of Drug Metabolism Enzyme Gene Polymorphism on Drug Response  

Yangjie Zhong
Zhejiang Zhuji Medical Materials Co., Ltd, Zhuji, 311800, China
Author    Correspondence author
International Journal of Clinical Case Reports, 2024, Vol. 14, No. 1   doi: 10.5376/ijccr.2024.14.0007
Received: 12 Mar., 2024    Accepted: 13 Apr., 2024    Published: 24 Apr., 2024
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Preferred citation for this article:

Zhong Y.J., 2024, The impact of drug metabolism enzyme gene polymorphism on drug response, International Journal of Clinical Case Reports, 14(1): 55-62 (doi: 10.5376/ijccr.2024.14.0007)


The genetic polymorphism of drug metabolism enzymes is a highly concerned research direction in the field of drug therapy, and has made significant progress in medicine and clinical practice. The polymorphism of drug metabolism enzyme genes has broad clinical importance for drug response, and its research goal is to understand how patient genotype information shapes their response to specific drugs, so that doctors can better formulate personalized treatment plans. This not only helps to improve the safety and success rate of patients' treatment, but also provides important clues for the development of new drugs to create safer and more effective treatment methods, further promoting the development of the medical field. This review provides an in-depth understanding of how genetic polymorphisms affect individuals' metabolic rate of drugs and the individualization of drug therapy. It explores the close relationship between phenotypic polymorphisms and drug response, and combines specific case studies of drug therapy to provide new insights into improving medical outcomes.

Drug metabolizing enzymes; Genetic polymorphism; Drug response; Personalized medicine; Case study
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