Liqin Zhou

Zhuji Fourth People's Hospital, Zhuji, 311800, China
Author    Correspondence author
International Journal of Clinical Case Reports, 2024, Vol. 14, No. 2   
Received: 05 Apr., 2024    Accepted: 07 May, 2024    Published: 18 May, 2024

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

With the rise of the concept of personalized medicine, individual differences in drug response in medication have increasingly attracted widespread attention. Drug toxicity is a significant adverse reaction in drug therapy, resulting from the interaction of multiple factors, including the nature of the drug itself, the individual's physiological condition, and genetic variations. The mechanism of drug toxicity involves multiple levels. As a crucial factor, genetic variation may directly influence the activity of drug-metabolizing enzymes, thereby significantly affecting the metabolic rate and clearance of drugs. Genes such as those in the CYP family and transporter families play pivotal roles in drug metabolism pathways. Genetic variations may lead to alterations in the functions of these critical genes, impacting the metabolism and distribution of drugs within the body. This review, through a systematic literature review and comprehensive analysis, delves deeply into the close association between drug toxicity and specific genetic variations. The aim is to better predict patients' responses to drugs and provide a reference basis for formulating more precise treatment plans.

Drug toxicity; Genetic variation; Drug metabolism; Clinical practice; Personalized medicine