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Exploring Coronary Sinus Downsizing for Angina Treatment:Lessons from the ORBITA-COSMIC Experience ![](https://medscipublisher.com/templates/images/OA.gif)
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International Journal of Clinical Case Reports, 2024, Vol. 14, No. 2
Received: 22 Apr., 2024 Accepted: 29 Apr., 2024 Published: 03 May, 2024
The paper "Coronary sinus reducer for the treatment of refractory angina (ORBITA-COSMIC), published in The Lancet on April 20, 2024: a randomised, placebo-controlled trial", Written by Michael J. Foley, Christopher A. Rajkumar, F. Ahmed-Jushuf, et al. From Imperial College London, Midlands and South Essex NHS Foundation Trust, Anglia Ruskin University, etc. In this study, the researchers investigated the effects of coronary sinus reducers (CSR) in the treatment of refractory angina pectoris through the ORBITA-COSMIC trial. The study was conducted in six UK hospitals using a double-blind, randomized, placebo-controlled approach to assess the effectiveness of CSR compared to placebo in improving myocardial ischemia and angina symptoms. The study was conducted in patients over 18 years of age with stable coronary artery disease and myocardial ischemia who had no other treatment options. The results of the study showed that although the effect of CSR in improving myocardial blood flow was not significant, it had a significant effect compared to placebo in reducing the frequency of angina attacks. These findings provide a scientific basis for CSR as a new treatment option against angina pectoris.
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. Zhaoyi Zhao
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. Coronary sinus downsizing
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. Angina
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. Treatment
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. ORBITA-COSMIC
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