Jingqiang Wang

Cuixi Academy of Biotechnology, Zhuji, 311800, Zhejiang, China
Author    Correspondence author
International Journal of Clinical Case Reports, 2024, Vol. 14, No. 2   
Received: 25 Mar., 2024    Accepted: 27 Apr., 2024    Published: 08 May, 2024

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

The objective of this study is to examine advancements in engineering synthetic microbial communities aimed at enhancing probiotic functionality and improving gut health. The review focuses on the integration of synthetic biology tools, dietary influences, and the therapeutic applications of these engineered probiotics. Significant progress has been made in developing engineered probiotics capable of delivering therapeutics and responding to environmental cues within the gut. Key findings include the enhanced therapeutic potential of engineered probiotics for treating diseases such as inflammatory bowel disease and metabolic disorders, and the challenges posed by the complexity and adaptability of synthetic probiotics compared to native gut microbiota. Additionally, the integration of artificial intelligence and synthetic biology has significantly advanced personalized probiotic therapies. Despite these advancements, challenges remain in replicating the complexity of native microbiota and ensuring the long-term stability and efficacy of engineered probiotics. Future research should focus on interdisciplinary collaboration, integrating advanced technologies, and establishing robust regulatory frameworks to maximize the therapeutic potential of synthetic probiotics.

Synthetic microbial communities; Engineered probiotics; Gut health; Synthetic biology; Personalized medicine