wang wei

1 The Key Laboratory of Plant Resources Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), College of Tea Sciences/Institute of AgroBioengineering, Guiyang, 550025, Guizhou, China
2 Plant Conservation & Breeding Technology Center, Guizhou Key Laboratory of Agricultural Biotechnology / Biotechnology Institute of Guizhou Province, Guizhou Academy of Agricultural Sciences, Guiyang, 550006, Guizhou, China
Author    Correspondence author
International Journal of Clinical Case Reports, 2024, Vol. 14, No. 6   
Received: 24 Sep., 2024    Accepted: 30 Oct., 2024    Published: 29 Nov., 2024

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract Eucommia ulmoides, a traditional Chinese medicinal herb, contains various bioactive compounds such as iridoids, flavonoids, lignans, and phenylpropanoids, which show potential in antidiabetic applications. Metabolic engineering techniques can enhance the synthesis of these compounds, thereby increasing the medicinal value of Eucommia ulmoides. This study reviews the identified phytochemicals in Eucommia ulmoides and analyzes advanced techniques used for their identification, such as UPLC-Q-TOF-MS and HPLC/DAD-Q-TOF-MS/MS. Additionally, it discusses the biochemical pathways, key enzymes, and genes associated with Eucommia ulmoides, with a focus on newly discovered iridoid glycoside polymers and their significance in antidiabetic research. The findings indicate that metabolic engineering can significantly enhance the production of antidiabetic-related compounds in Eucommia ulmoides, supporting the development of novel natural antidiabetic drugs. Both in vitro and in vivo studies have shown that these compounds effectively lower blood glucose levels and improve insulin sensitivity. Understanding the bioactive compounds and metabolic pathways in Eucommia ulmoides is crucial for developing new antidiabetic drugs. Metabolic engineering not only helps increase the content of these compounds but also enables more precise drug development through modern techniques such as genome editing. Future research should continue exploring additional bioactive compounds and utilize advanced metabolic engineering techniques to further optimize their synthesis pathways.

Eucommia ulmoides; Bioactive compounds; Metabolic engineering; Antidiabetic; Genome editing