wang wei , Qin Wang , Degang Zhao

1 Key Laboratory of Cell Engineering of Guizhou Province, Affiliated Hospital of Zunyi Medical University, Zunyi, 563000, Guizhou, China
2 The Key Laboratory of Plant Resources Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), College of Life Sciences/Institute of AgroBioengineering,Guizhou University, Guiyang, 550025, Guizhou, China
3 Plant Conservation & Breeding Technology Center, Guizhou Key Laboratory of Agricultural Biotechnology/Biotechnology Institute of Guizhou Province, Guizhou Academy of Agricultural Sciences, Guiyang, 550006, Guizhou, China
Author    Correspondence author
International Journal of Clinical Case Reports, 2024, Vol. 14, No. 5   
Received: 30 Jul., 2024    Accepted: 02 Sep., 2024    Published: 04 Oct., 2024

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Eucommia ulmoides, a traditional Chinese medicinal herb, has been extensively studied for its hypotensive effects and underlying mechanisms. This study synthesizes findings from various studies to elucidate the antihypertensive properties of Eucommia ulmoides and its active components. Research indicates that Eucommia ulmoides lignans (EuL) significantly lower blood pressure in spontaneously hypertensive rats (SHRs) by modulating nitric oxide (NO) levels and the renin-angiotensin system (RAS), and by directly relaxing arterial vessels. Additionally, Eucommia ulmoides bark extract has been shown to reduce blood pressure and inflammation by regulating gut microbiota, particularly enriching the Parabacteroides strain, which contributes to its antihypertensive effects. The leaf extract, known as Tochu tea, and its component geniposidic acid, have also demonstrated blood pressure-lowering effects by improving renal hemodynamics and suppressing NADPH oxidase activity. Furthermore, lignan extracts from Eucommia ulmoides bark have been found to prevent hypertensive cardiac remodeling, likely through aldose reductase inhibition. These findings collectively highlight the potential of Eucommia ulmoides as a natural therapeutic agent for hypertension, acting through multiple mechanisms including vascular relaxation, modulation of gut microbiota, and inhibition of oxidative stress pathways.

Eucommia ulmoides; Hypertension; Nitric oxide; Renin-angiotensin system; Gut microbiota