Shudan Yan

Biotechnology Research Center, Cuixi Academy of Biotechnology, Zhuji, 311800, China
Author    Correspondence author
International Journal of Molecular Medical Science, 2024, Vol. 14, No. 1   doi: 10.5376/ijmms.2024.14.0004
Received: 01 Mar., 2024    Accepted: 10 Mar., 2024    Published: 12 Mar., 2024

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Yan S.D., 2024, Glucocorticoid receptor signaling: intricacies and therapeutic opportunities, International Journal of Molecular Medical Science, 14(1): 24-28 (doi: 10.5376/ijmms.2024.14.0004)

The paper "Glucocorticoid receiver signing: intricacies and thermal opportunities" published in the journal Trends in Biochemical Sciences on February 29, 2024, authored by Dorien Clarisse, Laura Van Moortel, Chlo é Van Leene, Kris Gevaert, Karolin De Bosscher, and others from the University of Bridget et al. This study delves into the signaling mechanism of glucocorticoid receptors (GR) and their potential therapeutic applications. GR, as a nuclear receptor (NR), plays a crucial role in regulating the treatment of inflammatory diseases and certain cancers. By reviewing the basic biological characteristics of GR, including its activation and nuclear translocation mechanisms in cells, this study discusses in detail the interaction between GR and chromatin, revealing how it regulates downstream gene expression by directly binding to DNA responsive elements or interacting with other transcription factors. In addition, new concepts in GR signaling were explored, such as the recruitment of co regulatory factors, the role of aggregate formation, and strategies to enhance therapeutic efficacy through interaction with other nuclear receptors. By integrating multiple technologies to study the conformation and modification of chromatin, we can gain a deeper understanding of the cell-specific effects of glucocorticoids (GCs), providing a new perspective for developing GR ligands and therapeutic strategies with fewer side effects. This study not only provides valuable insights into the complex role of GR in cells, but also provides a theoretical basis for the development of new therapeutic methods in the future, especially in research aimed at reducing treatment-related side effects while improving efficacy.

Intricacies; Therapeutic opportunities