Wei Wang , Lingfei Jin

Biotechnology Research Center, Cuixi Academy of Biotechnology, Zhuji, 311800, China
Author    Correspondence author
International Journal of Molecular Medical Science, 2024, Vol. 14, No. 1   doi: 10.5376/ijmms.2024.14.0007
Received: 01 Mar., 2024    Accepted: 30 Mar., 2024    Published: 08 Apr., 2024

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Wang W., and Jin L.F., 2024, The development and clinical transformation of gene therapy in cardiovascular diseases, International Journal of Molecular Medical Science, 14(1): 48-55 (doi: 10.5376/ijmms.2024.14.0007)

Cardiovascular disease is one of the major causes of death worldwide, posing a huge burden on human health. Gene therapy, as an emerging treatment method, has the potential to change traditional treatment modes. This review aims to explore the development and clinical translation of gene therapy in cardiovascular diseases. This review systematically reviews the research progress of gene therapy related to cardiovascular diseases, including angiogenesis and repair, myocardial protection and reconstruction, as well as inflammation and immune regulation. In addition, the clinical trials of gene therapy that have been conducted were reviewed and their challenges and opportunities were discussed. The paper further prospects the prospects of gene therapy in cardiovascular diseases and explores the applications of personalized gene therapy and precision medicine. This review aims to provide a comprehensive overview and reference for the application and research of gene therapy in cardiovascular diseases.

Gene therapy; Cardiovascular disease; Clinical conversion; Personalized treatment