Manman Li

Hainan Institute of Tropical Agricultural Resources, Sanya, 572024, Hainan, China
Author    Correspondence author
International Journal of Molecular Medical Science, 2024, Vol. 14, No. 2   
Received: 26 Mar., 2024    Accepted: 16 Apr., 2024    Published: 27 Apr., 2024

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

The paper titled "Phosphatidylserine-exposing extracellular vesicles in body fluids are an innate defence against apoptotic mimicry viral pathogens" was published in the journal "Nature Microbiology" on March 25, 2024. Authored by Rüdiger Groß, Hanna Reßin, and Janis A. Müller, the research was conducted at the Institute of Molecular Virology at the University Medical Center Ulm, Germany, and the Institute of Virology at Philipps University of Marburg, Germany. The study reveals that extracellular vesicles (EVs) in body fluids combat viral infections by exposing phosphatidylserine (PS), which disrupts viral attachment and entry, thus serving an antiviral function. The results indicate that these EVs can effectively inhibit several viruses, including Dengue, West Nile, Chikungunya, Ebola, and Vesicular stomatitis viruses. However, they show lower inhibitory effects on SARS-CoV-2, HIV-1, Hepatitis C, and Herpes viruses due to these pathogens utilizing different receptor mechanisms for cell infection.

Innate defense; Extracellular vesicles; Phosphatidylserine; Combating apoptotic; Mimicry viruses