Jingqiang Wang

Institute of Life Science, Jiyang College of Zhejiang A&F University, Zhuji, 311800, Zhejiang, China
Author    Correspondence author
International Journal of Molecular Medical Science, 2024, Vol. 14, No. 2   
Received: 03 Mar., 2024    Accepted: 14 Apr., 2024    Published: 22 Apr., 2024

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

This study delves into the intricate communication network between the gastrointestinal tract and the central nervous system, known as the gut-brain axis, and its significant impact on mental health. The study focuses on the potential of engineered synthetic microbial consortia (SynComs) in regulating neurotransmitter production and promoting mental well-being. By examining recent advancements in synthetic biology and multi-omics technologies, it highlights the substantial improvements in SynComs' ability to precisely target neurochemical pathways. The integration potential of personalized SynComs in the treatment of mental health disorders is emphasized, offering a promising alternative to traditional therapies. Additionally, the study discusses the challenges related to technology, safety, ethics, and regulation, providing a comprehensive overview of the current state and future prospects of SynComs in clinical applications. The importance of interdisciplinary collaboration in advancing SynCom research is underscored, calling for continued efforts to fully realize its therapeutic potential. This study demonstrates the transformative potential of SynComs in the field of mental health, providing a theoretical foundation for innovative and personalized therapeutic strategies.

Gut-brain axis; Neurotransmitter modulation; Synthetic microbial communities; Mental health; Synthetic biology