Haiyan Chen^1,2 , Pengfei Hu³ , Li Liang⁴ , Ke Li¹ , Binghui Liu¹ , Liujing Zhou¹ , Xinci Zheng¹

1 College of Life Sciences, Changchun Sci-Tech University, Changchun, 130022, Heilongjiang, China;
2 College of Pharmacy, Changchun University of Chinese Medicine, Changchun, 130117, Heilongjiang, China;
3 Institute of Antler Science and Product Technology, Changchun Sci-Tech University, Changchun, 130012, Heilongjiang, China;
4 School of Food Science and Technology, Jiangnan University, Wuxi, 214122, Jiangsu, China
Author    Correspondence author
International Journal of Molecular Medical Science, 2024, Vol. 14, No. 6   
Received: 14 Sep., 2024    Accepted: 22 Oct., 2024    Published: 06 Nov., 2024

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

This study explores the antitumor effects and molecular mechanisms of Sanghuangporus polysaccharides. As the main active components of the traditional medicinal mushroom, Sanghuangporus polysaccharides exhibit significant antioxidant, immunomodulatory, and antitumor activities. They inhibit tumor growth by regulating the cell cycle, promoting apoptosis, and reducing cancer cell migration and invasion. Sanghuangporus polysaccharides exert antitumor effects by activating the p53 signaling pathway and down-regulating the expression of matrix metalloproteinases (MMPs). Additionally, their antioxidant properties help alleviate the side effects of chemotherapy and radiation therapy in cancer patients. Sanghuangporus polysaccharides can also be used for cancer prevention and adjuvant therapy, making them a promising natural therapeutic agent.

Sanghuangporus polysaccharides; Antitumor effects; Apoptosis; Oxidative stress; Cancer therapy