The Origin and Development Status of Smallpox Vaccine  

Wei Wang1 , Linfei Jin1,2
1 Cuixi Academy of Biotechnology, Zhuji, 311800, China
2 Institute of Life Science, Jiyang College of Zhejiang A&F University, Zhuji, 311800, China
Author    Correspondence author
Journal of Vaccine Research, 2023, Vol. 13, No. 1   doi: 10.5376/jvr.2023.13.0001
Received: 08 Jun., 2023    Accepted: 15 Jun., 2023    Published: 20 Jun., 2023
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This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Preferred citation for this article:

Wang W., and Jin L.F., 2023, The origin and development status of smallpox vaccine, Journal of Vaccine Research, 13(1): 1-6 (doi: 10.5376/jvr.2023.13.0001)


Smallpox virus (Variola, VAR) belongs to the Orthopoxvirus genus and has caused a global smallpox pandemic in history, causing profound disasters to humanity. Since Edward Jenner (1749-1823), a famous British doctor, scientist, and founder of modern immunology, discovered the subtle connection between cowpox and smallpox and carried out the first vaccination in the 18th century, many domestic and foreign scholars have devoted themselves to the research of smallpox vaccines, saving millions of lives. The emergence and elimination of smallpox virus is a long process. The effectiveness of traditional smallpox vaccines has been fully verified, but they can cause many side effects, requiring the development of safer and more effective smallpox vaccines. This review summarizes the origin of smallpox and the current development status of smallpox vaccines by reviewing domestic and international literature related to smallpox vaccines. Expanding the stockpile of smallpox vaccines has become a global need, and the development of new smallpox vaccines is of great significance in increasing user compliance, improving vaccine immunity and safety.

Smallpox vaccine; Development; Smallpox virus (Variola)
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