Jessi J. White

Author    Correspondence author
Journal of Vaccine Research, 2024, Vol. 14, No.   
Received: 01 Jan., 1970    Accepted: 01 Jan., 1970    Published: 11 Oct., 2024

Abstract Dengue fever remains a significant public health challenge in tropical and subtropical regions worldwide, and there is an urgent need for a safe and effective vaccine to combat the disease. This study provides a comprehensive analysis of the progress in dengue vaccine development, with a particular focus on the efficacy, safety, and implementation of current vaccines. The research reviews the historical background and initial development of Dengvaxia, the first licensed dengue vaccine, and explores ongoing trials of next-generation vaccines such as TAK-003, which hold promise for broader and safer protection. The study also discusses the challenges faced in vaccine rollout and assesses the impact of vaccination on dengue incidence and hospitalization rates, presenting case studies of both successful and unsuccessful implementation experiences. This research aims to provide a theoretical foundation for the development of more effective and safer dengue vaccines. Keywords Dengue Vaccine; Dengvaxia; TAK-003; Vaccine Efficacy; Vaccine Safety