Researchers Solve 'Protein Paradox' and Suggest Way to Exploit Cancer Weakness
Published:02 Nov.2020 Source:University of Copenhagen The Faculty of Health and Medical Sciences
Researchers have discovered how thus far a mysterious function of the so-called MCM proteins protect the human cells against DNA instability, which can cause devastating diseases including cancer. In addition to their known role as molecular motors of genome duplication, MCM proteins control the speed of this process.
How cells manage to constrain the speed of DNA replication has puzzled researchers for decades and has even been called a 'MCM paradox'.