Researchers Identify Molecule That Blocks Immune Cells from Entering and Killing Breast Tumors
Published:11 Nov.2021 Source:George Washington University
George Washington University researchers have identified a key molecule in certain kinds of breast cancers that prevent immune cells from entering tumors and killing the cancer cells inside. The paper and its findings, published today in Nature, could pave the way toward a new treatment for certain kinds of aggressive breast cancer.
"During cancer progression, this molecule, known as DDR1, organizes a high-order extracellular matrix that acts like barbed wire around the boundary of a tumor to prevent immune cells from entering the tumor," Rong Li, the Ross Professor of Basic Science Research at GW and lead author of the paper, said. "Knowing that the DDR1 molecule creates a protective boundary around tumors, we were able to use pre-clinical models to show that the moment you deactivate DDR1, immune cells can infiltrate the tumor and kill the cells inside."