Revolutionary Nanodrones Enable Targeted Cancer Treatment
Published:19 Feb.2024 Source:Ulsan National Institute of Science and Technology (UNIST)
A groundbreaking study led by Professor Sebyung Kang and Professor Sung Ho Park in the Department of Biological Sciences at UNIST has unveiled a remarkable breakthrough in cancer treatment. The research team has successfully developed unprecedented "NK cell-engaging nanodrones" capable of selectively targeting and eliminating cancer cells, offering a potential solution for intractable types of cancers. The innate lymphoid cells known as natural killer (NK) cells play a vital role in the body's immune response against cancer.
Now, the research team has designed and fabricated exceptional NK cell-engaging nanodrones, referred to as NKeNDs, using AaLS protein cage nanoparticles. The physical engagement of human NK cells with the target cancer cells mediated by the NKeNDs activates the NK cells, enabling them to effectively eliminate the target cancer cells in vitro. This groundbreaking study showcases a novel approach to developing cancer-specific NK cell engagers by utilizing protein cage nanoparticles and recombinant cancer cell binders.
This research presents new possibilities for immune treatment through NK cell delivery nanodrones, overcoming challenges such as the movement and survival of NK cells. Researchers aim to provide new opportunities for customized treatments that selectively address various types of cancer through further research, including cancer-specific immune cell induction.